Scientific Book

Body Homeostasis And The Endocannabinoid System And Cannabidiol in Sports Performance

HOMEOSTASIS, ECS & CBD

Restoring Athlete Balance Wth ECS-Based Strategies

This book explores the interplay between physiological homeostasis and the endocannabinoid system (ECS) as it relates to athletic performance and recovery. It examines key molecules such as β-alanine, sodium bicarbonate, glutamine, iron, and cannabidiol (CBD), detailing their roles in buffering pH, modulating inflammation, and regulating CNS stress responses. With practical protocols aligned to anti-doping regulations, this volume integrates evidence-based support systems to enhance performance, recovery, and athlete resilience across competition cycles.

Authored by Ionei Matos de Góis, Carmen Melo do Vale, Hildomar Batista dos Santos, Ronaldo Christofoletti, and Lucas Augusto Rodrigues de Oliveira, this volume blends clinical expertise in nutrology, sports medicine, and physiological biochemistry. It offers athletes and practitioners actionable guidance to optimize acid-base balance, micronutrient intake, and ECS modulation for sustainable performance and well-being.

CORE PHYSIOLOGY

ECS Balance, pH Buffering & CBD Mechanisms

Physical exercise elevates endocannabinoids like anandamide (AEA), contributing to mood enhancement, pain relief, and neuroplasticity—known colloquially as the “runner’s high”. Cannabidiol (CBD), exempted from WADA’s prohibited list, may heighten ECS activity by inhibiting FAAH, thus boosting AEA levels and engaging CB2-mediated anti-inflammatory pathways. These interactions support stress adaptation, recovery, and tissue resiliency—though current proof remains predominantly preclinical, the physiological promise is compelling.

Book Highlights

Runner’s High via ECS Activation: Explores how physical exercise elevates anandamide levels, engaging CB1 receptors to promote mood balance, pain relief, and neuroplasticity—foundational elements for recovery and emotional resilience via the body’s own endocannabinoid system.
CBD as a Recovery Modulator: Details CBD's potential to inhibit FAAH and elevate anandamide, thereby supporting anti-inflammatory and neuroprotective pathways. Early evidence highlights possible benefits for recovery, even though strong clinical validation in athletics is still pending.
Acid-Base Buffering with Ergogenic Aids: Reviews how β-alanine (increasing muscle carnosine) and sodium bicarbonate (enhancing extracellular buffering) work together to counteract exercise-induced acidosis—especially effective in high-intensity efforts lasting up to ~10 minutes.
CBD, Sleep, and Post-Exercise Comfort: Summarizes emerging data suggesting that CBD may improve sleep latency and quality, reduce inflammation and muscle soreness, and lower anxiety levels—offering a promising route for athletes to enhance recovery cycles.

Why is this book indispensable?

Bridges Exercise to Mood and Pain Relief

Demonstrates how physical activity boosts endocannabinoid levels—especially anandamide—engaging the ECS to diminish pain, elevate mood, and support mental resilience, fundamental for performance and recovery. These mechanisms are increasingly recognized as central to the elusive “runner’s high” and emerge consistently in current research.

Highlights CBD’s Promise for Recovery, Sleep, and Inflammation Control

Summarizes emerging evidence indicating that CBD may improve sleep quality, ease anxiety, and mitigate post-exercise inflammation by modulating ECS pathways and cytokine expression. While large-scale human trials are pending, preliminary findings suggest real-world relevance for athletes seeking enhanced recovery.

Transforms Biochemical Insight into Tactical Strategies for Athletes

Connects foundational physiology—ECS functioning, acid-base buffering, and CBD actions—with practical applications: optimized sleep protocols, recovery supplements, and anti-inflammatory plans grounded in emerging evidence, empowering support teams to apply safe and science-backed interventions in training design and recovery frameworks.

Who is this book essential for?

Sports Medicine Physicians & Functional Health Clinicians

For medical professionals, this book deciphers the role of the endocannabinoid system in exercise-induced well-being, from pain modulation and inflammation control to neuroprotection—insights vital in post-injury care and holistic recovery strategies.

Performance Coaches & Athletic Trainers

Provides practical, science-backed tools like β-alanine and sodium bicarbonate protocols for managing acid–base balance and insights into CBD’s emerging role in sleep optimization and post-exercise recovery. Helps refine recovery programming and performance resilience.

Sports Nutritionists & Dietitians

Equips nutrition professionals with the biochemical understanding and applied strategies needed to support athletes’ metabolism, inflammation, and recovery—bridging ECS regulation, nutraceutical selection, and dietary adaptation within regulatory frameworks.

Athlete Support Teams & Recovery Specialists

A must-read for support personnel managing athlete welfare. It brings together ECS-informed recovery, sleep enhancement techniques with CBD, and careful supplementation strategies—helping optimize routines without risking anti-doping compliance.

Janaíne Hoffmann Búrigo, MD

I graduated in Medicine from the Catholic University of Pelotas/RS in 1996, followed by Geriatrics and Gerontology training at Hospital São Lucas, PUCRS. I studied Orthomolecular Practice and Applied Nutrigenomics in São Paulo/SP and Tissue Regeneration in Campinas/SP, becoming a Founding Member of the Brazilian Society of Tissue Regeneration. Currently finalizing Nutritional Medicine certification with the Brazilian Association of Nutritional Medicine and authoring several international publications, I practice in Florianópolis, conducting comprehensive assessments and personalized oral and parenteral nutritional therapies guided by genetic-metabolic and epigenetic profiling, all grounded in scientific evidence and ethical standards to support quality longevity.

Melissa Nunes Leandro, MD

I graduated in Medicine from Centro Universitário do Pará/Brazil in 2018 and am currently pursuing a specialization in Female Nutritional Medicine. With a passionate focus on weight loss and obesity, I dedicate my career to promoting my patients’ health and well-being through comprehensive, evidence-based care. As a specialist in hypertrophy, I believe that true transformation goes beyond physical change, encompassing holistic quality-of-life improvements. I approach every individual with tailored programs that consider metabolic, lifestyle, and psychological factors, combining scientific rigor with empathetic support. I invite you to join me on this journey of self-discovery and sustainable transformation toward lasting vitality.

Lorena Barros Bianchini, MD

I graduated in Medicine from Centro Universitário do Pará in 2016 and subsequently specialized in Geriatrics and Nutritional Medicine. After transformative personal experiences—motherhood, overcoming postpartum depression, and a profound journey of self-discovery—I found my true calling in integrative medicine focused on weight management and longevity. As an entrepreneur, I completed a fellowship in Integrative Medicine and Healthcare Management, and today I lead a multidisciplinary clinic at the Medical Center in Imperatriz, MA, where we deliver deeply humanized, strategic care that honors body, mind, and behavior. Beyond clinical practice, I create educational and inspiring content on social media, empowering women to reclaim self-esteem, health, and focus.

Alexandre Chaves, MD

I am an Anesthesiologist with over 30 years of dedicated practice, having worked tirelessly throughout the pandemic and honored for my significant social and humanitarian service. Driven by a deep empathy for those I care for and a keen ability to absorb the latest scientific advancements, I have, for nearly six years, embarked on a new path in Medicine: Nutritional Medicine. I am passionate about promoting healthy lifestyle choices—including balanced nutrition, regular physical activity, and restorative time in nature—and I integrate these principles into every patient interaction. This evolving focus represents the culmination of my long and fruitful journey, combining my extensive anesthesiology expertise with a holistic approach to wellness that empowers individuals to achieve lasting health.

Manuela Bandeira da Silva Filha, MD

I am an General Practitioner who graduated from the University of Gurupi (UNIRG) in Tocantins/Brazil. From the very start of my medical training, I immersed myself in understanding “Health” as an integrative process of improving both body and mind. With a steadfast commitment to patient transformation, I guide individuals toward their goals through psychological support, appropriate pharmacotherapy, and—most importantly—sustainable lifestyle changes. To deepen my expertise, I completed two postgraduate programs in Nutrology and Orthomolecular Medicine, each emphasizing a patient-centered philosophy rather than a disease-centered one. My passion is to empower patients to achieve lasting well-being by addressing the root causes of imbalance and fostering holistic self-care.

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